InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TRAF3

Summary

InnateDB Protein

IDBP-585812.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRAF3

Protein Name

TNF receptor-associated factor 3

Synonyms

CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1;

Species

Homo sapiens

Ensembl Protein

ENSP00000454207

InnateDB Gene

IDBG-21240 (TRAF3)

Protein Structure

UniProt Annotation

Function

Regulates pathways leading to the activation of NF- kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein ligase activity and promote 'Lys-63'-linked ubiquitination of target proteins. Inhibits activation of NF-kappa-B in response to LTBR stimulation. Inhibits TRAF2-mediated activation of NF-kappa- B. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14. {ECO:0000269PubMed:15084608, ECO:0000269PubMed:15383523, ECO:0000269PubMed:17991829, ECO:0000269PubMed:19937093, ECO:0000269PubMed:20097753, ECO:0000269PubMed:20185819}.

Subcellular Localization

Cytoplasm {ECO:0000305}. Endosome {ECO:0000250}. Mitochondrion. Note=Undergoes endocytosis together with TLR4 upon LPS signaling (By similarity). Associated with mitochondria in response to virus. {ECO:0000250}.

Disease Associations

Herpes simplex encephalitis 3 (HSE3) [MIM:614849]: A rare complication of human herpesvirus 1 (HHV-1) infection, occurring in only a small minority of HHV-1 infected individuals. HSE is characterized by hemorrhagic necrosis of parts of the temporal and frontal lobes. Onset is over several days and involves fever, headache, seizures, stupor, and often coma, frequently with a fatal outcome. {ECO:0000269PubMed:20832341}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 195 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.

Experimentally validated
Total	195 [view]
Protein-Protein	192 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	27 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0004871	signal transducer activity
GO:0005164	tumor necrosis factor receptor binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0019901	protein kinase binding
GO:0031625	ubiquitin protein ligase binding
GO:0031996	thioesterase binding

Biological Process

GO:0001817	regulation of cytokine production
GO:0002224	toll-like receptor signaling pathway
GO:0002756	MyD88-independent toll-like receptor signaling pathway
GO:0006915	apoptotic process
GO:0007165	signal transduction
GO:0008063	Toll signaling pathway
GO:0016567	protein ubiquitination
GO:0030162	regulation of proteolysis
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0032480	negative regulation of type I interferon production
GO:0032648	regulation of interferon-beta production
GO:0033209	tumor necrosis factor-mediated signaling pathway
GO:0034138	toll-like receptor 3 signaling pathway
GO:0034142	toll-like receptor 4 signaling pathway
GO:0035666	TRIF-dependent toll-like receptor signaling pathway
GO:0042981	regulation of apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0050688	regulation of defense response to virus