InnateDB Protein
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IDBP-585821.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TMEM129
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Protein Name
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transmembrane protein 129
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000441812
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InnateDB Gene
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IDBG-6851 (TMEM129)
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Protein Structure
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Function |
E3 ubiquitin-protein ligase involved in ER-associated protein degradation, preferentially associates with the E2 enzyme UBE2J2. Exploited by viral US11 proteins to mediate HLA class I proteins degradation. {ECO:0000269PubMed:24807418}.
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Subcellular Localization |
Endoplasmic reticulum membrane {ECO:0000269PubMed:24807418}; Multi-pass membrane protein {ECO:0000269PubMed:24807418}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
|
Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR018801
Putative transmembrane protein precursor
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PFAM |
PF10272
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
A0AVI4
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PhosphoSite |
PhosphoSite-A0AVI4
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
92305
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UniGene |
Hs.518562
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RefSeq |
XP_005248095
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HUGO |
HGNC:25137
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OMIM |
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CCDS |
CCDS46998
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HPRD |
14290
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IMGT |
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EMBL |
AC016773
BC009331
BC126370
CH471131
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GenPept |
AAI26371
EAW82569
EAW82570
EAW82571
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