Version 5.4
Homo sapiens Protein: TTLL5
Summary
InnateDB Protein IDBP-585860.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TTLL5
Protein Name tubulin tyrosine ligase-like family, member 5
Synonyms CORD19; KIAA0998; STAMP;
Species Homo sapiens
Ensembl Protein ENSP00000452524
InnateDB Gene IDBG-13099 (TTLL5)
Protein Structure
UniProt Annotation
Function Polyglutamylase which preferentially modifies alpha- tubulin. Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step (By similarity). Required for CCSAP localization to both spindle and cilia microtubules. Increases the effects of NCOA2 in glucocorticoid receptor-mediated repression and induction and in androgen receptor-mediated induction. {ECO:0000250, ECO:0000269PubMed:17116691, ECO:0000269PubMed:22493317}.
Subcellular Localization Cell projection, cilium {ECO:0000250}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250}. Nucleus {ECO:0000269PubMed:17116691}. Cytoplasm {ECO:0000269PubMed:17116691}. Note=In ciliated cells, located in both cilia and basal bodies (By similarity). In osteosarcoma cells, found in both cytoplasm and nucleus in the absence of steroid but located exclusively in the nucleus in the presence of steroid. {ECO:0000250}.
Disease Associations
Tissue Specificity Widely expressed with highest levels in heart and skeletal muscle and low levels in other tissues. {ECO:0000269PubMed:17116691}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0016874 ligase activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006464 cellular protein modification process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005929 cilium
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6EMB2
PhosphoSite PhosphoSite-Q6EMB2
TrEMBL O95419
UniProt Splice Variant
Entrez Gene 23093
UniGene Hs.709609
RefSeq
HUGO HGNC:19963
OMIM 612268
CCDS
HPRD 08309
IMGT
EMBL AB023215 AC007182 AC009399 AF107885 AK024259 AL136808 AY237126 BC002766 BC136472 BC136473 CH471061 CR533554
GenPept AAC79729 AAF23275 AAH02766 AAI36473 AAI36474 AAP75557 BAA76842 BAB14862 CAB66742 CAG38585 EAW81247

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca