InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ENO2

Summary

InnateDB Protein

IDBP-586063.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ENO2

Protein Name

enolase 2 (gamma, neuronal)

Synonyms

HEL-S-279; NSE;

Species

Homo sapiens

Ensembl Protein

ENSP00000438873

InnateDB Gene

IDBG-15559 (ENO2)

Protein Structure

UniProt Annotation

Function

Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Can translocate to the plasma membrane in either the homodimeric (alpha/alpha) or heterodimeric (alpha/gamma) form. {ECO:0000250}.

Disease Associations

Tissue Specificity

The alpha/alpha homodimer is expressed in embryo and in most adult tissues. The alpha/beta heterodimer and the beta/beta homodimer are found in striated muscle, and the alpha/gamma heterodimer and the gamma/gamma homodimer in neurons.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 49 experimentally validated interaction(s) in this database.

Experimentally validated
Total	49 [view]
Protein-Protein	45 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004634	phosphopyruvate hydratase activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006006	glucose metabolic process
GO:0006094	gluconeogenesis
GO:0006096	glycolytic process
GO:0044281	small molecule metabolic process

Cellular Component

GO:0000015	phosphopyruvate hydratase complex
GO:0005615	extracellular space
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000941 Enolase
IPR020810 Enolase, C-terminal
IPR020811 Enolase, N-terminal
IPR022662 Methylaspartate ammonia-lyase, C-terminal
IPR029017 Enolase N-terminal domain-like
IPR029065 Enolase C-terminal domain-like

PFAM

PF00113
PF03952
PF07476

PRINTS

PR00148

PIRSF

PIRSF001400

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt