InnateDB Protein
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IDBP-586234.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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HNF1A
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Protein Name
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HNF1 homeobox A
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Synonyms
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HNF-1A; HNF1; IDDM20; LFB1; MODY3; TCF-1; TCF1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000445445
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InnateDB Gene
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IDBG-61093 (HNF1A)
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Protein Structure
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Function |
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 357 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated |
Total |
357
[view]
|
Protein-Protein |
50
[view]
|
Protein-DNA |
307
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
|
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Predicted by orthology |
Total |
8 [view]
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Molecular Function |
Accession |
GO Term |
GO:0001077
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RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
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GO:0003677
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DNA binding
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GO:0003700
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sequence-specific DNA binding transcription factor activity
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GO:0005515
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protein binding
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GO:0042803
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protein homodimerization activity
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GO:0043565
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sequence-specific DNA binding
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GO:0044212
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transcription regulatory region DNA binding
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GO:0046982
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protein heterodimerization activity
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GO:0046983
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protein dimerization activity
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Biological Process |
GO:0006351
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transcription, DNA-templated
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GO:0006357
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regulation of transcription from RNA polymerase II promoter
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GO:0030073
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insulin secretion
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GO:0035623
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renal glucose absorption
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GO:0042593
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glucose homeostasis
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GO:0045893
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positive regulation of transcription, DNA-templated
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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GO:0046323
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glucose import
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GO:0060261
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positive regulation of transcription initiation from RNA polymerase II promoter
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Cellular Component |
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PDB ID |
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InterPro |
IPR006899
Hepatocyte nuclear factor 1, N-terminal
IPR023219
Hepatocyte nuclear factor 1, dimerisation domain
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PFAM |
PF04814
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P20823
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PhosphoSite |
PhosphoSite-P20823
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TrEMBL |
B8YNU9
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UniProt Splice Variant |
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Entrez Gene |
6927
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UniGene |
Hs.654455
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RefSeq |
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HUGO |
HGNC:11621
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OMIM |
142410
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CCDS |
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HPRD |
00800
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IMGT |
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EMBL |
AC079602
BC104908
BC104910
CH471054
EF641294
FJ550192
FJ550194
FJ550195
FJ550197
FJ550200
FJ550201
FJ550202
HM116552
HM116557
HM116558
HM449088
HM449089
M57732
U72612
U72613
U72614
U72615
U72616
U72617
U72618
X71346
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GenPept |
AAA88077
AAC51137
AAI04909
AAI04911
ABR09270
ACL15382
ACL15384
ACL15385
ACL15387
ACL15390
ACL15391
ACL15392
ADK56177
ADK56178
ADM43489
ADM43494
ADM43495
CAB59201
EAW98226
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