InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ACO1

Summary

InnateDB Protein

IDBP-586247.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACO1

Protein Name

aconitase 1, soluble

Synonyms

ACONS; HEL60; IREB1; IREBP; IREBP1; IRP1;

Species

Homo sapiens

Ensembl Protein

ENSP00000438733

InnateDB Gene

IDBG-55575 (ACO1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	12 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0003994	aconitate hydratase activity
GO:0005515	protein binding
GO:0030350	iron-responsive element binding
GO:0046872	metal ion binding
GO:0051539	4 iron, 4 sulfur cluster binding

Biological Process

GO:0006099	tricarboxylic acid cycle
GO:0006101	citrate metabolic process
GO:0008152	metabolic process
GO:0010040	response to iron(II) ion

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000573 Aconitase A/isopropylmalate dehydratase small subunit, swivel
IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha
IPR006249 Aconitate/iron regulatory protein 2
IPR015928 Aconitase/3-isopropylmalate dehydratase, swivel

PFAM

PF00694
PF00330

PRINTS

PR00415

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite