InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DDX6

Summary

InnateDB Protein

IDBP-586250.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DDX6

Protein Name

DEAD (Asp-Glu-Ala-Asp) box polypeptide 6

Synonyms

HLR2; P54; RCK;

Species

Homo sapiens

Ensembl Protein

ENSP00000433704

InnateDB Gene

IDBG-74041 (DDX6)

Protein Structure

UniProt Annotation

Function

In the process of mRNA degradation, may play a role in mRNA decapping.

Subcellular Localization

Cytoplasm, P-body {ECO:0000269PubMed:16364915, ECO:0000269PubMed:16699599, ECO:0000269PubMed:20616046, ECO:0000269PubMed:22915799}.

Disease Associations

Note=A chromosomal aberration involving DDX6 may be a cause of hematopoietic tumors such as B-cell lymphomas. Translocation t(11;14)(q23;q32).

Tissue Specificity

Abundantly expressed in most tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 65 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	65 [view]
Protein-Protein	65 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003724	RNA helicase activity
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008026	ATP-dependent helicase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0006200	ATP catabolic process
GO:0010467	gene expression
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0033962	cytoplasmic mRNA processing body assembly
GO:0043928	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay

Cellular Component

GO:0000932	cytoplasmic mRNA processing body
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0010494	cytoplasmic stress granule
GO:0016020	membrane
GO:0016442	RISC complex
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

InterPro

IPR001650 Helicase, C-terminal
IPR011545 DEAD/DEAH box helicase domain
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR014014 RNA helicase, DEAD-box type, Q motif
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00271
PF00270

PRINTS

PIRSF

SMART

SM00490
SM00487

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P26196