InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ZNF141

Summary

InnateDB Protein

IDBP-5863.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZNF141

Protein Name

zinc finger protein 141

Synonyms

D4S90; PAPA6; pHZ-44;

Species

Homo sapiens

Ensembl Protein

ENSP00000240499

InnateDB Gene

IDBG-5861 (ZNF141)

Protein Structure

UniProt Annotation

Function

May be involved in transcriptional regulation as a repressor. Plays a role in limb development. {ECO:0000269PubMed:23160277}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Polydactyly, postaxial A6 (PAPA6) [MIM:615226]: A condition characterized by the occurrence of supernumerary digits in the upper and/or lower extremities. In postaxial polydactyly type A, the extra digit is well-formed and articulates with the fifth or a sixth metacarpal/metatarsal. {ECO:0000269PubMed:23160277}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Ubiquitously low expression.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0009653	anatomical structure morphogenesis
GO:0035108	limb morphogenesis