Version 5.4
Homo sapiens Protein: KRTAP5-9
Summary
InnateDB Protein IDBP-586319.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KRTAP5-9
Protein Name keratin associated protein 5-9
Synonyms KRN1; KRTAP5-1; KRTAP5.9;
Species Homo sapiens
Ensembl Protein ENSP00000431443
InnateDB Gene IDBG-545296 (KRTAP5-9)
Protein Structure
UniProt Annotation
Function In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins.
Subcellular Localization
Disease Associations
Tissue Specificity Restricted to hair root, not detected in any other tissues. Expressed in cuticle layers of differentiating hair follicles. {ECO:0000269PubMed:15144888}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0008544 epidermis development
Cellular Component
GO:0045095 keratin filament
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P26371
PhosphoSite PhosphoSite-P26371
TrEMBL
UniProt Splice Variant
Entrez Gene 3846
UniGene Hs.709220
RefSeq NP_005544
HUGO HGNC:23604
OMIM 148021
CCDS CCDS53677
HPRD 01008
IMGT
EMBL AB126078 AJ006693 BC069531 BC101744 X55293 X63755
GenPept AAH69531 AAI01745 BAD20205 CAA07189 CAA39005 CAA45283

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca