InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MXD1

Summary

InnateDB Protein

IDBP-586406.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MXD1

Protein Name

MAX dimerization protein 1

Synonyms

BHLHC58; MAD; MAD1;

Species

Homo sapiens

Ensembl Protein

ENSP00000443935

InnateDB Gene

IDBG-55075 (MXD1)

Protein Structure

UniProt Annotation

Function

Transcriptional repressor. MAD binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MAD thus antagonizes MYC transcriptional activity by competing for MAX.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	33 [view]
Protein-Protein	27 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003712	transcription cofactor activity
GO:0003714	transcription corepressor activity
GO:0046983	protein dimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0007275	multicellular organismal development
GO:0008283	cell proliferation