InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CRADD

Summary

InnateDB Protein

IDBP-586447.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CRADD

Protein Name

CASP2 and RIPK1 domain containing adaptor with death domain

Synonyms

MRT34; RAIDD;

Species

Homo sapiens

Ensembl Protein

ENSP00000439068

InnateDB Gene

IDBG-51368 (CRADD)

Protein Structure

UniProt Annotation

Function

Apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. In the presence of RIP and TRADD, CRADD recruits caspase-2 to the TNFR-1 signalling complex.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.

Disease Associations

Mental retardation, autosomal recessive 34 (MRT34) [MIM:614499]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRT34 is a non-syndromic form. Affected individuals have mildly delayed development and significantly impaired cognitive function, precluding independent living and self-care. Speech is rudimentary, but articulate; autism is not present. {ECO:0000269PubMed:22279524}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Constitutively expressed in most tissues, with particularly high expression in adult heart, testis, liver, skeletal muscle, fetal liver and kidney.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.

Experimentally validated
Total	26 [view]
Protein-Protein	20 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0005515	protein binding
GO:0030674	protein binding, bridging
GO:0070513	death domain binding

Biological Process

GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007165	signal transduction
GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors
GO:0042981	regulation of apoptotic process
GO:0071260	cellular response to mechanical stimulus
GO:2001235	positive regulation of apoptotic signaling pathway