InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CASP1

Summary

InnateDB Protein

IDBP-586548.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CASP1

Protein Name

caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)

Synonyms

ICE; IL1BC; P45;

Species

Homo sapiens

Ensembl Protein

ENSP00000434250

InnateDB Gene

IDBG-69618 (CASP1)

Protein Structure

UniProt Annotation

Function

Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. {ECO:0000269PubMed:15498465, ECO:0000269PubMed:7876192}.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Expressed in larger amounts in spleen and lung. Detected in liver, heart, small intestine, colon, thymus, prostate, skeletal muscle, peripheral blood leukocytes, kidney and testis. No expression in the brain. {ECO:0000269PubMed:15498465}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 82 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	82 [view]
Protein-Protein	79 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004175	endopeptidase activity
GO:0004197	cysteine-type endopeptidase activity
GO:0005515	protein binding
GO:0008234	cysteine-type peptidase activity
GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process

Biological Process

GO:0006508	proteolysis
GO:0006915	apoptotic process
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007165	signal transduction
GO:0035872	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087	innate immune response (InnateDB)
GO:0050727	regulation of inflammatory response
GO:0071260	cellular response to mechanical stimulus
GO:0071310	cellular response to organic substance
GO:0097194	execution phase of apoptosis

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0072557	IPAF inflammasome complex
GO:0072558	NLRP1 inflammasome complex
GO:0072559	NLRP3 inflammasome complex
GO:0097169	AIM2 inflammasome complex

Protein Structure and Domains

PDB ID

InterPro

IPR001309 Peptidase C14, ICE, catalytic subunit p20
IPR002138 Peptidase C14, caspase non-catalytic subunit p10
IPR011600 Peptidase C14, caspase domain
IPR015917 Peptidase C14A, caspase precursor p45, core

PFAM

PF00656

PRINTS

PR00376

PIRSF

SMART

SM00115

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt