Version 5.4
Homo sapiens Protein: AKAP3
Summary
InnateDB Protein IDBP-586672.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AKAP3
Protein Name A kinase (PRKA) anchor protein 3
Synonyms AKAP 110; AKAP110; CT82; FSP95; HEL159; PRKA3; SOB1;
Species Homo sapiens
Ensembl Protein ENSP00000440994
InnateDB Gene IDBG-13126 (AKAP3)
Protein Structure
UniProt Annotation
Function May function as a regulator of both motility- and head- associated functions such as capacitation and the acrosome reaction.
Subcellular Localization Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250}. Note=Ribs of the fibrous sheath in the principal piece of the sperm tail. Dorsal margin of the acrosomal segment.
Disease Associations
Tissue Specificity Testis specific; only expressed in spermatids.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007338 single fertilization
GO:0007340 acrosome reaction
Cellular Component
GO:0001669 acrosomal vesicle
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR018292 A-kinase anchor 110kDa, C-terminal
IPR018459 RII binding domain
IPR020799 A-kinase anchor 110kDa
PFAM PF05716
PF10522
PRINTS
PIRSF
SMART SM00807
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O75969
PhosphoSite PhosphoSite-O75969
TrEMBL V9HWD4
UniProt Splice Variant
Entrez Gene 10566
UniGene Hs.98397
RefSeq NP_006413
HUGO HGNC:373
OMIM 604689
CCDS CCDS8531
HPRD 05256
IMGT
EMBL AC005832 AF087003 AF093408 AK292451 BC047535 EU794681 U85715
GenPept AAC35854 AAC63371 AAD21218 AAH47535 ACJ13735 BAF85140

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca