InnateDB Protein
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IDBP-586697.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CTNNA2
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Protein Name
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catenin (cadherin-associated protein), alpha 2
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Synonyms
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CAP-R; CAPR; CT114; CTNR;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000441705
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InnateDB Gene
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IDBG-58519 (CTNNA2)
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Protein Structure
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Function |
May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system. Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:16182284}. Cytoplasm, cytoskeleton {ECO:0000250}. Cell junction, adherens junction {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cell projection, axon {ECO:0000250}. Note=Recruited to the nucleus upon ZNF639 overexpression.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
6
[view]
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Protein-Protein |
6
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001033
Alpha-catenin
IPR006077
Vinculin/alpha-catenin
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PFAM |
PF01044
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PRINTS |
PR00805
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P26232
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PhosphoSite |
PhosphoSite-P26232
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
1496
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UniGene |
Hs.167368
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RefSeq |
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HUGO |
HGNC:2510
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OMIM |
114025
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CCDS |
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HPRD |
00228
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IMGT |
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EMBL |
AC008067
AC010975
AC011741
AC011746
AC016670
AC016716
AC093322
AC096573
AC096753
AC104780
AK127226
AK295181
AK295493
AK303035
BC052996
BX537769
CH471053
FJ695201
M94151
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GenPept |
AAA58407
AAH52996
AAX88946
AAX93241
AAY14758
AAY14763
AAY15008
AAY15073
BAG54457
BAH12003
BAH12088
BAH13884
CAD97832
EAW99564
EAW99565
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