InnateDB Protein
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IDBP-586801.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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VASH1
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Protein Name
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vasohibin 1
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Synonyms
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KIAA1036;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000451613
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InnateDB Gene
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IDBG-13421 (VASH1)
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Protein Structure
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Function |
Angiogenesis inhibitor. Inhibits migration, proliferation and network formation by endothelial cells as well as angiogenesis. This inhibitory effect is selective to endothelial cells as it does not affect the migration of smooth muscle cells or fibroblasts. Does not affect the proliferation of cancer cells in vitro, but inhibits tumor growth and tumor angiogenesis. Acts in an autocrine manner. Inhibits artery neointimal formation and macrophage infiltration. Exhibits heparin-binding activity. {ECO:0000269PubMed:15467828, ECO:0000269PubMed:16488400, ECO:0000269PubMed:16707096}.
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Subcellular Localization |
Secreted {ECO:0000269PubMed:15467828, ECO:0000269PubMed:16707096}.
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Disease Associations |
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Tissue Specificity |
Preferentially expressed in endothelial cells. Highly expressed in fetal organs. Expressed in brain and placenta, and at lower level in heart and kidney. Highly detected in microvessels endothelial cells of atherosclerotic lesions. {ECO:0000269PubMed:15467828, ECO:0000269PubMed:16707096}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q7L8A9
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PhosphoSite |
PhosphoSite-Q7L8A9
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
22846
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UniGene |
Hs.603576
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RefSeq |
XP_006720143
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HUGO |
HGNC:19964
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OMIM |
609011
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CCDS |
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HPRD |
12353
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IMGT |
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EMBL |
AB028959
AC007376
AF111169
AL832588
BC009031
BC051896
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GenPept |
AAD44361
AAF02829
AAH09031
AAH51896
BAA82988
CAD89941
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