Version 5.4
Homo sapiens Protein: FUNDC1
Summary
InnateDB Protein IDBP-58681.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FUNDC1
Protein Name FUN14 domain containing 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000367284
InnateDB Gene IDBG-58679 (FUNDC1)
Protein Structure
UniProt Annotation
Function Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control. {ECO:0000269PubMed:22267086}.
Subcellular Localization Mitochondrion outer membrane {ECO:0000269PubMed:22267086}; Multi-pass membrane protein {ECO:0000269PubMed:22267086}.
Disease Associations
Tissue Specificity Widely expressed. {ECO:0000269PubMed:22267086}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000422 mitochondrion degradation
GO:0001666 response to hypoxia
Cellular Component
GO:0005741 mitochondrial outer membrane
GO:0031307 integral component of mitochondrial outer membrane
Protein Structure and Domains
PDB ID
InterPro IPR007014 FUN14
PFAM PF04930
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8IVP5
PhosphoSite PhosphoSite-Q8IVP5
TrEMBL
UniProt Splice Variant
Entrez Gene 139341
UniGene Hs.7549
RefSeq NP_776155
HUGO HGNC:28746
OMIM 300871
CCDS CCDS14263
HPRD 06658
IMGT
EMBL AL022163 AL136137 BC035015 BC042813
GenPept AAH35015 AAH42813 CAI40461 CAI42944

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca