Version 5.4
Homo sapiens Protein: RALGAPA2
Summary
InnateDB Protein IDBP-58686.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RALGAPA2
Protein Name Ral GTPase activating protein, alpha subunit 2 (catalytic)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000202677
InnateDB Gene IDBG-58682 (RALGAPA2)
Protein Structure
UniProt Annotation
Function Catalytic subunit of the heterodimeric RalGAP2 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB. {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:16490346}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005096 GTPase activator activity
GO:0005488 binding
GO:0017123 Ral GTPase activator activity
GO:0046982 protein heterodimerization activity
Biological Process
GO:0032859 activation of Ral GTPase activity
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0061024 membrane organization
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR000331 Rap GTPase activating protein domain
IPR016024 Armadillo-type fold
PFAM PF02145
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q2PPJ7
PhosphoSite PhosphoSite-Q2PPJ7
TrEMBL
UniProt Splice Variant
Entrez Gene 57186
UniGene Hs.714195
RefSeq NP_065076
HUGO HGNC:16207
OMIM
CCDS CCDS46584
HPRD
IMGT
EMBL AB033098 AK022881 AL078634 AL121896 AL157718 AL161658 BC013749 DQ310704
GenPept AAH13749 ABC33805 BAA86586 BAB14290 CAC27348 CAI12810 CAI39939 CAI39940 CAI40814 CAI40815 CAI95625 CAI95626 CAI95627

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca