InnateDB Protein
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IDBP-58692.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SLC24A6
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Protein Name
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solute carrier family 24 (sodium/potassium/calcium exchanger), member 6
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000202831
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InnateDB Gene
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IDBG-58690 (SLC24A6)
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Protein Structure
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Function |
Mitochondrial sodium/calcium antiporter that mediates sodium-dependent calcium efflux from mitochondrion, thereby acting as a key regulator of mitochondrion calcium homeostasis. Regulates rates of glucose-dependent insulin secretion in pancreatic beta- cells during the first phase of insulin secretion: acts by mediating efflux of calcium from mitochondrion, thereby affecting cytoplasmic calcium responses. Able to transport Ca(2+) in exchange of either Li(+) or Na(+), explaining how Li(+) catalyzes Ca(2+) exchange. In contrast to other members of the family its function is independent of K(+). {ECO:0000269PubMed:15060069, ECO:0000269PubMed:20018762, ECO:0000269PubMed:22829870, ECO:0000269PubMed:23056385}.
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Subcellular Localization |
Mitochondrion inner membrane; Multi-pass membrane protein. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Mainly localizes to mitochondrion inner membrane.
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Disease Associations |
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Tissue Specificity |
Present in pancreatic beta-cells (at protein level). {ECO:0000269PubMed:23056385}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0005432
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calcium:sodium antiporter activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR004837
Sodium/calcium exchanger membrane region
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PFAM |
PF01699
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q6J4K2
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PhosphoSite |
PhosphoSite-Q6J4K2
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TrEMBL |
F8VWW9
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UniProt Splice Variant |
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Entrez Gene |
80024
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UniGene |
Hs.577439
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RefSeq |
NP_079235
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HUGO |
HGNC:26175
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OMIM |
609841
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CCDS |
CCDS31909
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HPRD |
15354
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IMGT |
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EMBL |
AC010178
AK025886
AY601759
AY601760
BC098360
CH471054
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GenPept |
AAH98360
AAT35807
AAT35808
BAB15271
EAW98050
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