InnateDB Protein
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IDBP-587157.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SLC48A1
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Protein Name
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solute carrier family 48 (heme transporter), member 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000446739
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InnateDB Gene
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IDBG-29040 (SLC48A1)
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Protein Structure
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Function |
Heme transporter that regulates intracellular heme availability through the endosomal or lysosomal compartment. {ECO:0000269PubMed:18418376}.
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Subcellular Localization |
Endosome membrane {ECO:0000269PubMed:18418376}; Multi-pass membrane protein {ECO:0000269PubMed:18418376}. Lysosome membrane {ECO:0000269PubMed:18418376}; Multi-pass membrane protein {ECO:0000269PubMed:18418376}.
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Disease Associations |
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Tissue Specificity |
Highly expressed in the brain, kidney, heart and skeletal muscle. Moderately expressed in the liver, lung, placenta and small intestine. {ECO:0000269PubMed:18418376}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0015232
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heme transporter activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q6P1K1
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PhosphoSite |
PhosphoSite-
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TrEMBL |
F8VQX9
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UniProt Splice Variant |
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Entrez Gene |
55652
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UniGene |
Hs.438867
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RefSeq |
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HUGO |
HGNC:26035
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OMIM |
612187
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CCDS |
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HPRD |
07916
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IMGT |
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EMBL |
AC004241
AC004466
AC137054
AK000496
BC002759
BC026344
BC065033
CH471111
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GenPept |
AAH02759
AAH26344
AAH65033
BAA91205
EAW57951
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