Version 5.4
Homo sapiens Protein: DUSP21
Summary
InnateDB Protein IDBP-58737.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DUSP21
Protein Name dual specificity phosphatase 21
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000343244
InnateDB Gene IDBG-58735 (DUSP21)
Protein Structure
UniProt Annotation
Function Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:12408986}. Nucleus {ECO:0000269PubMed:12408986}. Mitochondrion inner membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Matrix side {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in testis. {ECO:0000269PubMed:12408986}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004725 protein tyrosine phosphatase activity
GO:0008138 protein tyrosine/serine/threonine phosphatase activity
GO:0016791 phosphatase activity
GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity
Biological Process
GO:0000188 inactivation of MAPK activity
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation
GO:0035335 peptidyl-tyrosine dephosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005759 mitochondrial matrix
GO:0031314 extrinsic component of mitochondrial inner membrane
Protein Structure and Domains
PDB ID
InterPro IPR000340 Dual specificity phosphatase, catalytic domain
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR020417 Atypical dual specificity phosphatase
IPR020420 Atypical dual specificity phosphatase, subfamily B
IPR020422 Dual specificity phosphatase, subgroup, catalytic domain
IPR029021 Protein-tyrosine phosphatase-like
PFAM PF00782
PRINTS PR01908
PR01910
PIRSF
SMART SM00195
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H596
PhosphoSite PhosphoSite-Q9H596
TrEMBL
UniProt Splice Variant
Entrez Gene 63904
UniGene Hs.534478
RefSeq NP_071359
HUGO HGNC:20476
OMIM 300678
CCDS CCDS14264
HPRD 06494
IMGT
EMBL AF533018 AL133545 AY156515 BC119755 BC119756 CR457159
GenPept AAI19756 AAI19757 AAN59788 AAO17295 CAC10195 CAG33440

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca