Version 5.4
Homo sapiens Protein: EPS8L2
Summary
InnateDB Protein IDBP-587590.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EPS8L2
Protein Name EPS8-like 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000436035
InnateDB Gene IDBG-17790 (EPS8L2)
Protein Structure
UniProt Annotation
Function Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. {ECO:0000269PubMed:14565974}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:14565974}.
Disease Associations
Tissue Specificity Detected in fibroblasts and placenta. {ECO:0000269PubMed:14565974}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0030676 Rac guanyl-nucleotide exchange factor activity
Biological Process
GO:0007266 Rho protein signal transduction
GO:0032321 positive regulation of Rho GTPase activity
GO:0032855 positive regulation of Rac GTPase activity
GO:0035023 regulation of Rho protein signal transduction
GO:1900029 positive regulation of ruffle assembly
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0032587 ruffle membrane
GO:0043234 protein complex
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001452 SH3 domain
IPR006020 PTB/PI domain
IPR011511 Variant SH3 domain
IPR013625 Tensin phosphotyrosine-binding domain
IPR013761 Sterile alpha motif/pointed domain
PFAM PF00018
PF14604
PF00640
PF14719
PF07653
PF08416
PRINTS PR00452
PIRSF
SMART SM00326
SM00462
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H6S3
PhosphoSite PhosphoSite-Q9H6S3
TrEMBL E9PNY4
UniProt Splice Variant
Entrez Gene 64787
UniGene Hs.626905
RefSeq
HUGO HGNC:21296
OMIM 614988
CCDS CCDS31328
HPRD 10940
IMGT
EMBL AC131934 AF318331 AK025588 AK025824 AK027765 AK094539 AK222903 AP006621 AY074929 BC080636 BC093878 BC101481 BC143242
GenPept AAH80636 AAH93878 AAI01482 AAI43243 AAL55838 AAL76118 BAB15180 BAB15248 BAB55354 BAD96623 BAG52883

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca