InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ZNF580

Summary

InnateDB Protein

IDBP-587943.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZNF580

Protein Name

zinc finger protein 580

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000443957

InnateDB Gene

IDBG-247133 (ZNF580)

Protein Structure

UniProt Annotation

Function

Involved in the regulation of endothelial cell proliferation and migration. Mediates H(2)O(2)-induced leukocyte chemotaxis by elevating interleukin-8 production and may play a role in inflammation. May be involved in transcriptional regulation. {ECO:0000269PubMed:20382120, ECO:0000269PubMed:21830064}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:20382120, ECO:0000269PubMed:21599657}. Note=Colocalized with SMAD2 in the nucleus.

Disease Associations

Tissue Specificity

Expressed in endothelial cells. {ECO:0000269PubMed:21599657}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0001938	positive regulation of endothelial cell proliferation
GO:0002690	positive regulation of leukocyte chemotaxis
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006935	chemotaxis
GO:0006954	inflammatory response
GO:0010595	positive regulation of endothelial cell migration
GO:0010628	positive regulation of gene expression
GO:0032757	positive regulation of interleukin-8 production
GO:0070301	cellular response to hydrogen peroxide