InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: USP2

Summary

InnateDB Protein

IDBP-588007.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

USP2

Protein Name

ubiquitin specific peptidase 2

Synonyms

UBP41; USP9;

Species

Homo sapiens

Ensembl Protein

ENSP00000436952

InnateDB Gene

IDBG-74471 (USP2)

Protein Structure

UniProt Annotation

Function

Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Isoform 1 and isoform 4 possess both ubiquitin-specific peptidase and isopeptidase activities. Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity. Has no deubiquitinase activity against p53/TP53. Prevents MDM2-mediated degradation of MDM4. Plays a role in the G1/S cell-cycle progression in normal and cancer cells. Plays a role in the regulation of myogenic differentiation of embryonic muscle cells. {ECO:0000269PubMed:17290220, ECO:0000269PubMed:19838211, ECO:0000269PubMed:19917254}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Note=Localizes in the spermatid head in late-elongating spermatids in the thin area between the outer acrosomal membrane and the plasma membrane. {ECO:0000250}.Isoform 4: Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in mesangial cells of the kidney and in different types of glomerulonephritides (at protein level). {ECO:0000269PubMed:20403044}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 93 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	93 [view]
Protein-Protein	92 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004197	cysteine-type endopeptidase activity
GO:0004221	ubiquitin thiolesterase activity
GO:0004843	ubiquitin-specific protease activity
GO:0005515	protein binding
GO:0030332	cyclin binding
GO:0031625	ubiquitin protein ligase binding
GO:0036459	ubiquitinyl hydrolase activity
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0007049	cell cycle
GO:0007517	muscle organ development
GO:0016579	protein deubiquitination
GO:0045931	positive regulation of mitotic cell cycle
GO:0050821	protein stabilization