InnateDB Protein
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IDBP-588136.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CLK3
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Protein Name
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CDC-like kinase 3
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Synonyms
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PHCLK3; PHCLK3/152;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000431825
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InnateDB Gene
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IDBG-22269 (CLK3)
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Protein Structure
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Function |
Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. {ECO:0000269PubMed:19168442, ECO:0000269PubMed:9637771}.
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Subcellular Localization |
Isoform 1: Nucleus. Cytoplasm {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250}.Isoform 2: Nucleus speckle. Note=Co- localizes with serine- and arginine-rich (SR) proteins in the nuclear speckles.
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Disease Associations |
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Tissue Specificity |
Endothelial cells. {ECO:0000269PubMed:19168442}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 49 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
49
[view]
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Protein-Protein |
48
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
1
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P49761
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PhosphoSite |
PhosphoSite-P49761
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TrEMBL |
H3BRT8
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UniProt Splice Variant |
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Entrez Gene |
1198
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UniGene |
Hs.732460
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RefSeq |
XP_005254211
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HUGO |
HGNC:2071
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OMIM |
602990
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CCDS |
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HPRD |
04290
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IMGT |
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EMBL |
AC100835
BC002555
BC006103
BC019881
BT006993
CH471136
L29217
L29220
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GenPept |
AAA61483
AAA61484
AAH02555
AAH06103
AAH19881
AAP35639
EAW99321
EAW99322
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