InnateDB Protein
|
IDBP-588274.3
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
PPP6R3
|
Protein Name
|
protein phosphatase 6, regulatory subunit 3
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000433058
|
InnateDB Gene
|
IDBG-61449 (PPP6R3)
|
Protein Structure
|
|
Function |
Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. May have an important role in maintaining immune self-tolerance. {ECO:0000269PubMed:11401438, ECO:0000269PubMed:16769727}.
|
Subcellular Localization |
Cytoplasm. Nucleus.
|
Disease Associations |
|
Tissue Specificity |
Expressed in skeletal muscle, placenta, heart, pancreas, testis, brain, lung, liver, kidney, spleen, thymus, prostate, small intestine, colon and leukocytes. {ECO:0000269PubMed:11401438, ECO:0000269PubMed:16769727}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 62 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
62
[view]
|
Protein-Protein |
62
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
|
Biological Process |
GO:0043666
|
regulation of phosphoprotein phosphatase activity
|
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR007587
SIT4 phosphatase-associated protein family
IPR016024
Armadillo-type fold
|
PFAM |
PF04499
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q5H9R7
|
PhosphoSite |
PhosphoSite-Q5H9R7
|
TrEMBL |
Q9H880
|
UniProt Splice Variant |
|
Entrez Gene |
55291
|
UniGene |
Hs.706886
|
RefSeq |
NP_001157634
|
HUGO |
HGNC:1173
|
OMIM |
610879
|
CCDS |
CCDS53673
|
HPRD |
10703
|
IMGT |
|
EMBL |
AB046778
AF264779
AF264780
AK001920
AK023950
AK057250
AL834471
AP000807
AP001788
AP003096
BC007738
BC105933
BC105934
BC107599
CR749815
CR933658
DQ111954
|
GenPept |
AAG36934
AAG36935
AAH07738
AAI05934
AAI05935
AAI07600
AAZ99639
BAA91978
BAB13384
BAB14737
BAB71396
CAD39130
CAH18675
CAI45957
|
|
|