Version 5.4
Homo sapiens Protein: RPP40
Summary
InnateDB Protein IDBP-58831.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RPP40
Protein Name ribonuclease P/MRP 40kDa subunit
Synonyms bA428J1.3; RNASEP1;
Species Homo sapiens
Ensembl Protein ENSP00000369391
InnateDB Gene IDBG-58825 (RPP40)
Protein Structure
UniProt Annotation
Function Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
Subcellular Localization Nucleus, nucleolus {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004526 ribonuclease P activity
Biological Process
GO:0008033 tRNA processing
GO:0090501 RNA phosphodiester bond hydrolysis
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic
Cellular Component
GO:0005634 nucleus
GO:0005655 nucleolar ribonuclease P complex
Protein Structure and Domains
PDB ID
InterPro IPR013893 Ribonuclease P, Rpp40
PFAM PF08584
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O75818
PhosphoSite PhosphoSite-O75818
TrEMBL X6RLL4
UniProt Splice Variant
Entrez Gene 10799
UniGene Hs.624959
RefSeq NP_006629
HUGO HGNC:20992
OMIM 606117
CCDS CCDS34333
HPRD 09361
IMGT
EMBL AL359643 BC017871 U94317
GenPept AAC24114 AAH17871 CAH73740

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca