Version 5.4
Homo sapiens Protein: RALGAPA1
Summary
InnateDB Protein IDBP-588379.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RALGAPA1
Protein Name Ral GTPase activating protein, alpha subunit 1 (catalytic)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000451877
InnateDB Gene IDBG-4799 (RALGAPA1)
Protein Structure
UniProt Annotation
Function Catalytic subunit of the heterodimeric RalGAP1 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB. {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Translocated to the nucleus, when associated with TCF3/E12. {ECO:0000250}.
Disease Associations
Tissue Specificity Widely expressed. {ECO:0000269PubMed:15498464}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005096 GTPase activator activity
GO:0005488 binding
GO:0017123 Ral GTPase activator activity
GO:0046982 protein heterodimerization activity
Biological Process
GO:0032859 activation of Ral GTPase activity
GO:0051056 regulation of small GTPase mediated signal transduction
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR000331 Rap GTPase activating protein domain
IPR016024 Armadillo-type fold
PFAM PF02145
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6GYQ0
PhosphoSite PhosphoSite-Q6GYQ0
TrEMBL Q9H984
UniProt Splice Variant
Entrez Gene 253959
UniGene Hs.689613
RefSeq NP_001269973
HUGO HGNC:17770
OMIM 608884
CCDS
HPRD 12324
IMGT
EMBL AB020691 AB511280 AK022988 AK126975 AL137818 AL160231 AL162311 AL834362 AY596970 AY596971 BC042013 BC042045 BC150596
GenPept AAH42013 AAH42045 AAI50597 AAT49271 AAT49272 BAA74907 BAB14349 BAC86772 BAH83561 CAD39026

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca