InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SYNE2

Summary

InnateDB Protein

IDBP-588417.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SYNE2

Protein Name

spectrin repeat containing, nuclear envelope 2

Synonyms

EDMD5; Nesp2; Nesprin-2; NUA; NUANCE; SYNE-2; TROPH;

Species

Homo sapiens

Ensembl Protein

ENSP00000452570

InnateDB Gene

IDBG-8789 (SYNE2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	27 [view]
Protein-Protein	27 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding

Biological Process

Cellular Component

GO:0005634	nucleus
GO:0016235	aggresome
GO:0031965	nuclear membrane
GO:0045111	intermediate filament cytoskeleton

Protein Structure and Domains

PDB ID

InterPro

IPR001715 Calponin homology domain
IPR002017 Spectrin repeat
IPR018159 Spectrin/alpha-actinin
IPR022613 Calmodulin-regulated spectrin-associated protein, CH domain
IPR022682 Peptidase C2, calpain, large subunit, domain III

PFAM

PF00307
PF00435
PF11971
PF01067

PRINTS

PIRSF

SMART

SM00033
SM00150

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite