InnateDB Protein
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IDBP-588819.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ZNF521
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Protein Name
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zinc finger protein 521
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Synonyms
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EHZF; Evi3;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000440768
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InnateDB Gene
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IDBG-1767 (ZNF521)
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Protein Structure
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Function |
Transcription factor that can both act as an activator or a repressor depending on the context. Involved in BMP signaling and in the regulation of the immature compartment of the hematopoietic system. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved specification of B-cell lineage; this interaction preventing EBF1 to bind DNA and activate target genes. {ECO:0000269PubMed:14630787}.
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Subcellular Localization |
Nucleus {ECO:0000250}.
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Disease Associations |
Note=A chromosomal aberration involving ZNF521 is found in acute lymphoblastic leukemia. Translocation t(9;18)(p13;q11.2) with PAX5. The translocation generates the PAX5-ZNF521 oncogene consisting of the N-terminus part of PAX5 and the C-terminus part of ZNF521.
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Tissue Specificity |
Predominantly expressed in hematopoietic cells. Present in organs and tissues that contain stem and progenitor cells, myeloid and/or lymphoid: placenta, spleen, lymph nodes, thymus, bone marrow and fetal liver. Within the hematopoietic system, it is abundant in CD34(+) cells but undetectable in mature peripheral blood leukocytes, and its levels rapidly decrease during the differentiation of CD34(+) cells in response to hemopoietins. {ECO:0000269PubMed:14630787}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
5
[view]
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Protein-Protein |
5
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
3 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR007087
Zinc finger, C2H2
IPR015880
Zinc finger, C2H2-like
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PFAM |
PF00096
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PRINTS |
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PIRSF |
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SMART |
SM00355
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TIGRFAMs |
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Modification |
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SwissProt |
Q96K83
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PhosphoSite |
PhosphoSite-Q96K83
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TrEMBL |
J3QRW6
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UniProt Splice Variant |
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Entrez Gene |
25925
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UniGene |
Hs.625064
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RefSeq |
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HUGO |
HGNC:24605
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OMIM |
610974
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CCDS |
CCDS32806
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HPRD |
18350
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IMGT |
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EMBL |
AC104961
AC105114
AC110603
AF141339
AJ518106
AK021452
AK027354
AK074046
AL117615
BC113622
BC113648
CH471088
DQ845345
EF445043
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GenPept |
AAG49442
AAI13623
AAI13649
ABI33104
ACA06095
BAB13829
BAB55056
BAB84872
CAB56016
CAD57322
EAX01201
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