Version 5.4
Homo sapiens Protein: SCAF11
Summary
InnateDB Protein IDBP-588843.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SCAF11
Protein Name SR-related CTD-associated factor 11
Synonyms CASP11; SFRS2IP; SIP1; SRRP129; SRSF2IP;
Species Homo sapiens
Ensembl Protein ENSP00000449812
InnateDB Gene IDBG-28456 (SCAF11)
Protein Structure
UniProt Annotation
Function Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly. {ECO:0000269PubMed:9447963}.
Subcellular Localization Nucleus {ECO:0000269PubMed:9447963}.
Disease Associations
Tissue Specificity Widely expressed. {ECO:0000269PubMed:9224939}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000245 spliceosomal complex assembly
GO:0000375 RNA splicing, via transesterification reactions
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q99590
PhosphoSite PhosphoSite-Q99590
TrEMBL
UniProt Splice Variant
Entrez Gene 9169
UniGene Hs.210367
RefSeq
HUGO HGNC:10784
OMIM 603668
CCDS
HPRD 04720
IMGT
EMBL AC000015 AF030234 BC040951 CH471111 Y11251
GenPept AAC39565 AAH40951 CAA72121 EAW57892 EAW57894

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca