Version 5.4
Homo sapiens Protein: BTNL2
Summary
InnateDB Protein IDBP-588864.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BTNL2
Protein Name butyrophilin-like 2 (MHC class II associated)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000443364
InnateDB Gene IDBG-80783 (BTNL2)
Protein Structure
UniProt Annotation
Function Negative regulator of T-cell proliferation. {ECO:0000250}.
Subcellular Localization Membrane {ECO:0000269PubMed:15735647}; Single-pass type II membrane protein {ECO:0000269PubMed:15735647}. Note=Isoform 2 is present in the nuclear, vesicle and plasma membranes, isoform 3 is found in cytoplasmic vesicle structures and is not membrane bound.
Disease Associations Sarcoidosis 2 (SS2) [MIM:612387]: An idiopathic, systemic, inflammatory disease characterized by the formation of immune granulomas in involved organs. Granulomas predominantly invade the lungs and the lymphatic system, but also skin, liver, spleen, eyes and other organs may be involved. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. A nucleotide transition affecting a splice donor site results in the use of an alternative splice site and the production of isoform 3. Individuals expressing isoform 3 have a higher risk for sarcoidosis.
Tissue Specificity Expressed in brain, heart, kidney, liver, pancreas, ovary, leukocyte, small intestine, testis and thymus. {ECO:0000269PubMed:15735647}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
Cellular Component
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR007110 Immunoglobulin-like domain
IPR013162 CD80-like, immunoglobulin C2-set
PFAM PF08205
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UIR0
PhosphoSite PhosphoSite-Q9UIR0
TrEMBL
UniProt Splice Variant
Entrez Gene 56244
UniGene Hs.534471
RefSeq
HUGO HGNC:1142
OMIM 606000
CCDS
HPRD 12077
IMGT
EMBL AF186588 AF186589 AF186590 AF186591 AF186592 AF186593 AL034394 AL662796 AL670296 AL935032 AY684332 AY684333 AY881999 BC119668 BC127642 BX255945 CR753634 CR759917 Z84814
GenPept AAF05530 AAI19669 AAI27643 AAV91022 AAV91023 AAX35330 AAX35331 CAC69895 CAI17569 CAI17570 CAI18265 CAI18474 CAI18475 CAI18727 CAI42180 CAQ07562 CAQ08809

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca