InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TCF7L1

Summary

InnateDB Protein

IDBP-58891.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TCF7L1

Protein Name

transcription factor 7-like 1 (T-cell specific, HMG-box)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000282111

InnateDB Gene

IDBG-58889 (TCF7L1)

Protein Structure

UniProt Annotation

Function

Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis (By similarity). Down-regulates NQO1, leading to increased mitomycin c resistance. {ECO:0000250}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Detected in hair follicles and skin keratinocytes, and at lower levels in stomach epithelium. {ECO:0000269PubMed:9916915}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0006325	chromatin organization
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007420	brain development
GO:0008595	anterior/posterior axis specification, embryo
GO:0030111	regulation of Wnt signaling pathway
GO:0035019	somatic stem cell maintenance
GO:0043588	skin development
GO:0045892	negative regulation of transcription, DNA-templated
GO:0046022	positive regulation of transcription from RNA polymerase II promoter during mitosis
GO:0048319	axial mesoderm morphogenesis
GO:0048699	generation of neurons
GO:0048863	stem cell differentiation
GO:0060070	canonical Wnt signaling pathway
GO:2000036	regulation of stem cell maintenance