InnateDB Protein
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IDBP-588918.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CDC42EP2
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Protein Name
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CDC42 effector protein (Rho GTPase binding) 2
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Synonyms
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BORG1; CEP2;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000431660
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InnateDB Gene
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IDBG-56842 (CDC42EP2)
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Protein Structure
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Function |
Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts in a CDC42-dependent manner. {ECO:0000269PubMed:10490598, ECO:0000269PubMed:11035016}.
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Subcellular Localization |
Endomembrane system {ECO:0000269PubMed:11035016}; Peripheral membrane protein {ECO:0000269PubMed:11035016}. Cytoplasm, cytoskeleton {ECO:0000269PubMed:11035016}.
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Disease Associations |
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Tissue Specificity |
Highly expressed in the heart. Weakly expressed in the pancreas and liver. {ECO:0000269PubMed:10490598}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
6
[view]
|
Protein-Protein |
5
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0007015
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actin filament organization
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GO:0008360
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regulation of cell shape
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GO:0030036
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actin cytoskeleton organization
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GO:0030838
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positive regulation of actin filament polymerization
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GO:0031274
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positive regulation of pseudopodium assembly
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GO:0031334
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positive regulation of protein complex assembly
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GO:0032321
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positive regulation of Rho GTPase activity
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Cellular Component |
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PDB ID |
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InterPro |
IPR000095
CRIB domain
IPR017363
Cdc42 effector protein 2
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PFAM |
PF00786
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PRINTS |
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PIRSF |
PIRSF038036
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SMART |
SM00285
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TIGRFAMs |
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Modification |
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SwissProt |
O14613
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PhosphoSite |
PhosphoSite-O14613
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
10435
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UniGene |
Hs.741371
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RefSeq |
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HUGO |
HGNC:16263
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OMIM |
606132
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CCDS |
CCDS8099
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HPRD |
09363
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IMGT |
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EMBL |
AF001436
AF098290
AF163840
AF548903
AK315444
BC022337
BC075834
BT020004
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GenPept |
AAB81206
AAD16185
AAD48784
AAH22337
AAH75834
AAN39381
AAV38807
BAG37832
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