InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PLA2G7

Summary

InnateDB Protein

IDBP-588989.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLA2G7

Protein Name

phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)

Synonyms

LDL-PLA2; LP-PLA2; PAFAD; PAFAH;

Species

Homo sapiens

Ensembl Protein

ENSP00000445666

InnateDB Gene

IDBG-89956 (PLA2G7)

Protein Structure

UniProt Annotation

Function

Modulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. Has a specificity for substrates with a short residue at the sn-2 position. It is inactive against long-chain phospholipids.

Subcellular Localization

Secreted, extracellular space.

Disease Associations

Platelet-activating factor acetylhydrolase deficiency (PAFAD) [MIM:614278]: An enzymatic deficiency that results in exacerbated bodily response to inflammatory agents. It can be associated with several disease states including inflammatory gastrointestinal disorders, asthma and atopy. Asthmatic individuals with PAFAD may manifest aggravated respiratory symptoms. {ECO:0000269PubMed:8675689, ECO:0000269PubMed:9245731, ECO:0000269PubMed:9412624, ECO:0000269PubMed:9472966, ECO:0000269PubMed:9759612}. Note=The disease is caused by mutations affecting the gene represented in this entry.Asthma (ASTHMA) [MIM:600807]: The most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with wheezing due to spasmodic contraction of the bronchi. {ECO:0000269PubMed:10733466}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.Atopic hypersensitivity (ATOPY) [MIM:147050]: A condition characterized by predisposition to develop hypersensitivity reactions. Atopic individuals can develop eczema, allergic rhinitis and allergic asthma. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Tissue Specificity

Plasma.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003847	1-alkyl-2-acetylglycerophosphocholine esterase activity
GO:0005543	phospholipid binding
GO:0047499	calcium-independent phospholipase A2 activity

Biological Process

GO:0016042	lipid catabolic process
GO:0034374	low-density lipoprotein particle remodeling
GO:0034440	lipid oxidation
GO:0034441	plasma lipoprotein particle oxidation
GO:0044267	cellular protein metabolic process
GO:0050729	positive regulation of inflammatory response
GO:0090026	positive regulation of monocyte chemotaxis

Cellular Component

GO:0005576	extracellular region
GO:0034362	low-density lipoprotein particle

Protein Structure and Domains

PDB ID

InterPro

IPR005065 Platelet-activating factor acetylhydrolase
IPR016715 Platelet-activating factor acetylhydrolase, eucaryote
IPR029058 Alpha/Beta hydrolase fold

PFAM

PF03403

PRINTS

PIRSF

PIRSF018169

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q13093