InnateDB Protein
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IDBP-589014.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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RAP1GAP
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Protein Name
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RAP1 GTPase activating protein
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Synonyms
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RAP1GA1; RAP1GAP1; RAP1GAPII; RAPGAP;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000441661
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InnateDB Gene
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IDBG-93263 (RAP1GAP)
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Protein Structure
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Function |
GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state. {ECO:0000269PubMed:15141215}.
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Subcellular Localization |
Golgi apparatus membrane; Peripheral membrane protein.
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Disease Associations |
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Tissue Specificity |
Significant expression seen in the brain, kidney and pancreas. Abundant in the cerebral cortex and expressed at much lower levels in the spinal cord. Not detected in the lymphoid tissues. {ECO:0000269PubMed:9346962}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
25
[view]
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Protein-Protein |
24
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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|
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000331
Rap GTPase activating protein domain
IPR003109
GoLoco motif
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PFAM |
PF02145
PF02188
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PRINTS |
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PIRSF |
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SMART |
SM00390
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TIGRFAMs |
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Modification |
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SwissProt |
P47736
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PhosphoSite |
PhosphoSite-P47736
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TrEMBL |
Q5T3T1
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UniProt Splice Variant |
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Entrez Gene |
5909
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UniGene |
Hs.148178
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RefSeq |
NP_001139129
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HUGO |
HGNC:9858
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OMIM |
600278
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CCDS |
CCDS53276
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HPRD |
02609
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IMGT |
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EMBL |
AB003930
AB007943
AL359815
BC054490
CH471134
M64788
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GenPept |
AAA60252
AAH54490
BAA32319
BAA83674
CAI16250
CAI16255
EAW94980
EAW94981
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