InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GAD1

Summary

InnateDB Protein

IDBP-589095.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GAD1

Protein Name

glutamate decarboxylase 1 (brain, 67kDa)

Synonyms

CPSQ1; GAD; SCP;

Species

Homo sapiens

Ensembl Protein

ENSP00000434696

InnateDB Gene

IDBG-74724 (GAD1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	5 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004351	glutamate decarboxylase activity
GO:0005515	protein binding
GO:0016829	lyase activity
GO:0016831	carboxy-lyase activity
GO:0030170	pyridoxal phosphate binding

Biological Process

GO:0006520	cellular amino acid metabolic process
GO:0006538	glutamate catabolic process
GO:0006540	glutamate decarboxylation to succinate
GO:0007268	synaptic transmission
GO:0007269	neurotransmitter secretion
GO:0018352	protein-pyridoxal-5-phosphate linkage
GO:0019752	carboxylic acid metabolic process
GO:0042136	neurotransmitter biosynthetic process

Cellular Component

GO:0005622	intracellular
GO:0005886	plasma membrane
GO:0012506	vesicle membrane
GO:0061202	clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001597 Aromatic amino acid beta-eliminating lyase/threonine aldolase
IPR002129 Pyridoxal phosphate-dependent decarboxylase
IPR015424 Pyridoxal phosphate-dependent transferase

PFAM

PF01212
PF00282

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q99259

PhosphoSite