InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LTB4R2

Summary

InnateDB Protein

IDBP-589178.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LTB4R2

Protein Name

leukotriene B4 receptor 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000432146

InnateDB Gene

IDBG-236766 (LTB4R2)

Protein Structure

UniProt Annotation

Function

Low-affinity receptor for leukotrienes including leukotriene B4. Mediates chemotaxis of granulocytes and macrophages. The response is mediated via G-proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTB4 > 12-epi-LTB4 > LTB5 > LTB3.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Widely expressed.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	3 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004974	leukotriene receptor activity

Biological Process

GO:0006935	chemotaxis
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007194	negative regulation of adenylate cyclase activity

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR003981 Leukotriene B4 receptor
IPR003982 Leukotriene B4 type 2 receptor
IPR017452 GPCR, rhodopsin-like, 7TM

PFAM

PF00001

PRINTS

PR00237
PR01476
PR01478

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite