Version 5.4
Homo sapiens Protein: RAP1GAP2
Summary
InnateDB Protein IDBP-589349.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RAP1GAP2
Protein Name RAP1 GTPase activating protein 2
Synonyms GARNL4; RAP1GA3;
Species Homo sapiens
Ensembl Protein ENSP00000439688
InnateDB Gene IDBG-16537 (RAP1GAP2)
Protein Structure
UniProt Annotation
Function GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state. {ECO:0000269PubMed:15632203}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:15632203}. Cytoplasm, perinuclear region {ECO:0000269PubMed:15632203}.
Disease Associations
Tissue Specificity Isoform 1 and isoform 2 are expressed in platelets with isoform 2 being the predominant form. Expressed in lymphocytes, heart, testis and pancreas. {ECO:0000269PubMed:15632203}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005096 GTPase activator activity
Biological Process
GO:0043547 positive regulation of GTPase activity
GO:0051056 regulation of small GTPase mediated signal transduction
Cellular Component
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0031965 nuclear membrane
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR000331 Rap GTPase activating protein domain
PFAM PF02145
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q684P5
PhosphoSite PhosphoSite-Q684P5
TrEMBL
UniProt Splice Variant
Entrez Gene 23108
UniGene Hs.685132
RefSeq
HUGO HGNC:29176
OMIM
CCDS
HPRD 17028
IMGT
EMBL AB028962 AJ628446 AJ628447 AK124640 BC140870 BC140871 CR627427
GenPept AAI40871 AAI40872 BAA82991 BAC85912 CAF31652 CAF31653 CAH10514

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca