InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TRIAP1

Summary

InnateDB Protein

IDBP-589355.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRIAP1

Protein Name

TP53 regulated inhibitor of apoptosis 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000449795

InnateDB Gene

IDBG-60567 (TRIAP1)

Protein Structure

UniProt Annotation

Function

Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane. Mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis. {ECO:0000269PubMed:15735003, ECO:0000269PubMed:23931759}.

Subcellular Localization

Cytoplasm, perinuclear region. Mitochondrion. Mitochondrion intermembrane space.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002039	p53 binding
GO:0005515	protein binding
GO:1990050	phosphatidic acid transporter activity

Biological Process

GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0015914	phospholipid transport
GO:0030330	DNA damage response, signal transduction by p53 class mediator
GO:0034644	cellular response to UV
GO:0043066	negative regulation of apoptotic process
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0090201	negative regulation of release of cytochrome c from mitochondria
GO:0097035	regulation of membrane lipid distribution
GO:1902166	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:2001140	positive regulation of phospholipid transport