InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LRRC4C

Summary

InnateDB Protein

IDBP-589387.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LRRC4C

Protein Name

leucine rich repeat containing 4C

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000436976

InnateDB Gene

IDBG-40253 (LRRC4C)

Protein Structure

UniProt Annotation

Function

May promote neurite outgrowth of developing thalamic neurons. {ECO:0000269PubMed:14595443}.

Subcellular Localization

Cell junction, synapse, postsynaptic cell membrane {ECO:0000269PubMed:14595443, ECO:0000269PubMed:21946559}; Single-pass type I membrane protein {ECO:0000269PubMed:14595443, ECO:0000269PubMed:21946559}.

Disease Associations

Tissue Specificity

Highly expressed in the cerebral cortex, including frontal, parietal and occipital lobes. Putamen, amygdala, hippocampus and medulla oblongata show moderate expression. Caudate nucleus and thalamus express small amounts, whereas other brain regions show very weak or no expression. {ECO:0000269PubMed:14595443}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0050770

regulation of axonogenesis

Cellular Component

GO:0005615	extracellular space
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0045211	postsynaptic membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000372 Leucine-rich repeat-containing N-terminal
IPR001611 Leucine-rich repeat
IPR003591 Leucine-rich repeat, typical subtype
IPR003596 Immunoglobulin V-set, subgroup
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin

PFAM