Version 5.4
Homo sapiens Protein: NME7
Summary
InnateDB Protein IDBP-589571.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NME7
Protein Name non-metastatic cells 7, protein expressed in (nucleoside-diphosphate kinase)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000433341
InnateDB Gene IDBG-104646 (NME7)
Protein Structure
UniProt Annotation
Function Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
Experimentally validated
Total 21 [view]
Protein-Protein 20 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004550 nucleoside diphosphate kinase activity
GO:0005524 ATP binding
GO:0046872 metal ion binding
Biological Process
GO:0006165 nucleoside diphosphate phosphorylation
GO:0006183 GTP biosynthetic process
GO:0006228 UTP biosynthetic process
GO:0006241 CTP biosynthetic process
Cellular Component
GO:0005813 centrosome
Protein Structure and Domains
PDB ID
InterPro IPR001564 Nucleoside diphosphate kinase
IPR006602 Uncharacterised domain DM10
IPR011410 Nucleoside diphosphate kinase, NDK7
PFAM PF00334
PRINTS PR01243
PIRSF PIRSF036503
SMART SM00562
SM00676
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y5B8
PhosphoSite PhosphoSite-Q9Y5B8
TrEMBL A0A024R8Z7
UniProt Splice Variant
Entrez Gene 29922
UniGene Hs.706952
RefSeq NP_932076
HUGO HGNC:20461
OMIM 613465
CCDS CCDS44274
HPRD 11394
IMGT
EMBL AF153191 AK094513 AK290701 AL031726 AL356852 BC006983 CH471067 Z99758
GenPept AAD34622 AAH06983 BAF83390 BAG52881 CAI18887 CAI19238 CAI22851 EAW90834 EAW90835 EAW90836

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca