InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ZFAND6

Summary

InnateDB Protein

IDBP-589645.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZFAND6

Protein Name

zinc finger, AN1-type domain 6

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000453291

InnateDB Gene

IDBG-25626 (ZFAND6)

Protein Structure

UniProt Annotation

Function

Involved in regulation of TNF-alpha induced NF-kappa-B activation and apoptosis. Involved in modulation of 'Lys-48'- linked polyubiquitination status of TRAF2 and decreases association of TRAF2 with RIPK1. Required for PTS1 target sequence-dependent protein import into peroxisomes and PEX5 stability; may cooperate with PEX6. In vitro involved in PEX5 export from the cytosol to peroxisomes (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed with high level in heart, skeletal muscle, liver, kidney and placenta. {ECO:0000269PubMed:11054541}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0031593	polyubiquitin binding

Biological Process

GO:0006625	protein targeting to peroxisome
GO:0006915	apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling
GO:0071356	cellular response to tumor necrosis factor