Version 5.4
Homo sapiens Protein: SYTL1
Summary
InnateDB Protein IDBP-589698.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SYTL1
Protein Name synaptotagmin-like 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000440704
InnateDB Gene IDBG-94845 (SYTL1)
Protein Structure
UniProt Annotation
Function May play a role in vesicle trafficking (By similarity). Binds phosphatidylinositol 3,4,5-trisphosphate. Acts as a RAB27A effector protein and may play a role in cytotoxic granule exocytosis in lymphocytes (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:11278853, ECO:0000269PubMed:18266782}; Peripheral membrane protein {ECO:0000269PubMed:11278853, ECO:0000269PubMed:18266782}; Cytoplasmic side {ECO:0000269PubMed:11278853, ECO:0000269PubMed:18266782}. Note=Peripheral membrane protein tightly bound to the cytoplasmic side of cellular membranes.
Disease Associations
Tissue Specificity Highly expressed in bone marrow and lymphoid tissues. Detected at lower levels in cerebellum, occipital lobe, prostate, stomach, kidney, appendix, lung and trachea. Expressed in cytotoxic T-lymphocytes (CTL). {ECO:0000269PubMed:11278853, ECO:0000269PubMed:18266782}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0017137 Rab GTPase binding
GO:0042043 neurexin family protein binding
Biological Process
GO:0006886 intracellular protein transport
GO:0006887 exocytosis
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0019897 extrinsic component of plasma membrane
GO:0042470 melanosome
Protein Structure and Domains
PDB ID
InterPro IPR000008 C2 domain
IPR010911 Zinc finger, FYVE-type
IPR011011 Zinc finger, FYVE/PHD-type
PFAM PF00168
PF02318
PRINTS PR00360
PIRSF
SMART SM00239
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8IYJ3
PhosphoSite PhosphoSite-Q8IYJ3
TrEMBL Q5SSC6
UniProt Splice Variant
Entrez Gene 84958
UniGene Hs.469175
RefSeq XP_005246079
HUGO HGNC:15584
OMIM 608042
CCDS CCDS53286
HPRD
IMGT
EMBL AK027902 AL663123 AY037157 BC009224 BC015764 BC035725 FO393419
GenPept AAH09224 AAH15764 AAH35725 AAK67636 BAB55444

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca