InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MAN2A2

Summary

InnateDB Protein

IDBP-590114.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAN2A2

Protein Name

mannosidase, alpha, class 2A, member 2

Synonyms

MANA2X;

Species

Homo sapiens

Ensembl Protein

ENSP00000452948

InnateDB Gene

IDBG-30540 (MAN2A2)

Protein Structure

UniProt Annotation

Function

Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway.

Subcellular Localization

Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004559	alpha-mannosidase activity
GO:0004572	mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity
GO:0008270	zinc ion binding
GO:0015923	mannosidase activity
GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds
GO:0030246	carbohydrate binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006013	mannose metabolic process
GO:0018279	protein N-linked glycosylation via asparagine
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0000139	Golgi membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000602 Glycoside hydrolase family 38, N-terminal domain
IPR011013 Galactose mutarotase-like domain
IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel
IPR011682 Glycosyl hydrolase family 38, C-terminal
IPR015341 Glycoside hydrolase, family 38, central domain
IPR028995 Glycoside hydrolase, families 57/38, central domain

PFAM

PF01074
PF07748
PF09261

PRINTS

PIRSF

SMART

SM00872

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P49641