InnateDB Protein
|
IDBP-590148.3
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
IFT81
|
Protein Name
|
intraflagellar transport 81 homolog (Chlamydomonas)
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000449718
|
InnateDB Gene
|
IDBG-56856 (IFT81)
|
Protein Structure
|
|
Function |
Component of the intraflagellar transport (IFT) complex B: together with IFT74, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds tubulin via its CH (calponin-homology)-like region. Required for ciliogenesis. {ECO:0000269PubMed:23990561}.
|
Subcellular Localization |
Cell projection, cilium {ECO:0000305PubMed:23990561}.
|
Disease Associations |
|
Tissue Specificity |
Highly expressed in testis, moderately in ovary, heart, liver, skeletal muscle, kidney and pancreas, low in prostate, brain, placenta and lung and not detected in spleen, thymus, small intestine and colon. Isoform CDV-1R is abundantly expressed in testis. {ECO:0000269PubMed:12549821}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
3
[view]
|
Protein-Protein |
3
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
2 [view]
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
|
PFAM |
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q8WYA0
|
PhosphoSite |
PhosphoSite-Q8WYA0
|
TrEMBL |
A0A024RBJ1
|
UniProt Splice Variant |
|
Entrez Gene |
28981
|
UniGene |
Hs.528382
|
RefSeq |
NP_001137251
|
HUGO |
HGNC:14313
|
OMIM |
605489
|
CCDS |
CCDS41831
|
HPRD |
09266
|
IMGT |
|
EMBL |
AF078932
AF139540
AF250326
AF332010
AK091549
BC004536
BC029349
BC108257
CH471054
|
GenPept |
AAD48091
AAH04536
AAH29349
AAI08258
AAL50343
AAO32947
AAP97269
BAC03690
EAW97898
EAW97899
EAW97901
|
|
|