Homo sapiens Protein: KLRF2
Summary
InnateDB Protein IDBP-590354.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KLRF2
Protein Name killer cell lectin-like receptor subfamily F, member 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000438244
InnateDB Gene IDBG-545174 (KLRF2)
Protein Structure
UniProt Annotation
Function C-type lectin-like receptor involved in natural killer cell mediated cytotoxicity and cytokine secretion in keratinocytes via its interaction with CLEC2A. {ECO:0000269PubMed:20194751}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:20194751}; Single-pass type II membrane protein {ECO:0000269PubMed:20194751}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0030246 carbohydrate binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0043320 natural killer cell degranulation
GO:0050663 cytokine secretion
Cellular Component
GO:0005887 integral component of plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR001304 C-type lectin
IPR002353 Type-2 ice-structuring protein
IPR016187 C-type lectin fold
PFAM PF00059
PRINTS PR00356
PIRSF
SMART SM00034
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt D3W0D1
PhosphoSite PhosphoSite-D3W0D1
TrEMBL
UniProt Splice Variant
Entrez Gene 100431172
UniGene Hs.725113
RefSeq NP_001177694
HUGO HGNC:37646
OMIM
CCDS CCDS53743
HPRD
IMGT
EMBL AC091814 GQ398770
GenPept ADC80446