InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SNCB

Summary

InnateDB Protein

IDBP-59053.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SNCB

Protein Name

synuclein, beta

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000308057

InnateDB Gene

IDBG-59051 (SNCB)

Protein Structure

UniProt Annotation

Function

Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53- dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Expressed predominantly in brain; concentrated in presynaptic nerve terminals.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004859	phospholipase inhibitor activity
GO:0005509	calcium ion binding
GO:0043014	alpha-tubulin binding
GO:0048487	beta-tubulin binding

Biological Process

GO:0007268	synaptic transmission
GO:0042417	dopamine metabolic process
GO:0043086	negative regulation of catalytic activity
GO:0043524	negative regulation of neuron apoptotic process
GO:0050808	synapse organization

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005794	Golgi apparatus
GO:0030426	growth cone
GO:0043025	neuronal cell body
GO:0043195	terminal bouton
GO:0043679	axon terminus
GO:0045202	synapse