InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PELI3

Summary

InnateDB Protein

IDBP-59062.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PELI3

Protein Name

pellino homolog 3 (Drosophila)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000322532

InnateDB Gene

IDBG-59060 (PELI3)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1. Can activate AP1/JUN and ELK1. Not required for NF-kappa-B activation. {ECO:0000269PubMed:12874243, ECO:0000269PubMed:17675297}.

Subcellular Localization

Disease Associations

Tissue Specificity

Highly expressed in brain, heart and testis, and at lower level in kidney, liver, lung, placenta, small intestine, spleen and stomach. Isoform 1 is not expressed in lung. {ECO:0000269PubMed:12874243}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0016874	ligase activity

Biological Process

GO:0008063	Toll signaling pathway
GO:0010804	negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0016567	protein ubiquitination
GO:0031397	negative regulation of protein ubiquitination
GO:0032480	negative regulation of type I interferon production
GO:0045087	innate immune response (InnateDB)
GO:0045751	negative regulation of Toll signaling pathway
GO:0050829	defense response to Gram-negative bacterium
GO:0070428	regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
GO:0070434	positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0070534	protein K63-linked ubiquitination
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway