InnateDB Protein
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IDBP-590783.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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NPSR1
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Protein Name
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neuropeptide S receptor 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000434955
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InnateDB Gene
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IDBG-12085 (NPSR1)
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Protein Structure
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Function |
May be active in signaling pathway in an autocrine or paracrine fashion in several tissues. Receptor for neuropeptide S, it may mediate its action, such as inhibitory effects, on cell growth. Involved in pathogenesis of asthma and other IgE-mediated diseases. {ECO:0000269PubMed:15312648, ECO:0000269PubMed:15947423}.
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Subcellular Localization |
Isoform 1: Cell membrane; Multi-pass membrane protein.Isoform 3: Cell membrane; Multi-pass membrane protein.Isoform 4: Cell membrane; Multi-pass membrane protein.Isoform 2: Cytoplasm.Isoform 5: Cytoplasm.Isoform 6: Cytoplasm.Isoform 7: Cytoplasm.Isoform 9: Cytoplasm.
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Disease Associations |
Asthma-related traits 2 (ASRT2) [MIM:608584]: Asthma- related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy and atopic dermatitis. {ECO:0000269PubMed:15073379, ECO:0000269PubMed:15710598, ECO:0000269PubMed:15764725}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
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Tissue Specificity |
Ubiquitous. Isoform 1 is predominantly expressed in smooth muscle. Isoform 4 is predominantly expressed in epithelial cells. In bronchial biopsies, it is expressed in smooth muscle cells of asthma patients, but not in control patients; whereas in epithelial cells, its expression is consistently stronger in asthma patients. {ECO:0000269PubMed:15073379, ECO:0000269PubMed:15947423}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
1
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0005000
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vasopressin receptor activity
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GO:0008188
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neuropeptide receptor activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q6W5P4
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PhosphoSite |
PhosphoSite-Q6W5P4
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
387129
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UniGene |
Hs.652373
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RefSeq |
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HUGO |
HGNC:23631
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OMIM |
608595
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CCDS |
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HPRD |
10547
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IMGT |
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EMBL |
AK172847
AY310326
AY310327
AY310328
AY310329
AY310330
AY310331
AY310332
AY956446
AY956447
AY956448
BC132693
BC132695
CH471073
DQ272236
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GenPept |
AAI32694
AAI32696
AAQ76966
AAQ76967
AAQ76968
AAQ76969
AAQ76970
AAQ76971
AAQ76972
AAX63744
AAX63745
AAX63746
ABB72550
BAD18811
EAW94036
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