InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RAB3IP

Summary

InnateDB Protein

IDBP-591266.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RAB3IP

Protein Name

RAB3A interacting protein (rabin3)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000448027

InnateDB Gene

IDBG-47346 (RAB3IP)

Protein Structure

UniProt Annotation

Function

Guanine nucleotide exchange factor (GEF) which may activate RAB8A and RAB8B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP- bound form. Mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5. Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface. Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. {ECO:0000269PubMed:12221131, ECO:0000269PubMed:20890297, ECO:0000269PubMed:20937701}.

Subcellular Localization

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Note=Predominantly cytoplasmic but a small proportion colocalizes with SSX2 in the nucleus. Activation of protein kinase C results in redistribution to the periphery of lamellipodia. In the cytoskeleton, localizes to cortical actin.

Disease Associations

Tissue Specificity

Expressed in brain, kidney, heart, pancreas and placenta. Not detected in skeletal muscle or liver. {ECO:0000269PubMed:12007189, ECO:0000269PubMed:12221131}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0017112	Rab guanyl-nucleotide exchange factor activity

Biological Process

GO:0006893	Golgi to plasma membrane transport
GO:0015031	protein transport
GO:0032851	positive regulation of Rab GTPase activity
GO:0033365	protein localization to organelle
GO:0042384	cilium assembly